There really are no good nicknames for Dwayne.
Famous people named Dwayne:
Writer Dwayne Wayans; football players Dwayne Allen and Dwayne Bowe; actor Dwayne Johnson; rapper Dwayne Carter (a.k.a. Lil' Wayne);
Fans of the '80s and '90s sitcom "A Different World" will remember main character Dwayne Wayne, played by Kadeem Hardison.